No. ReSeal does not affect tire balance when installed at the recommended volume. However, the tire needs to be balanced before installing ReSeal.
Will ReSeal work on bead leaks?
A bead leak in a tubeless tire may require that the tire be removed from the vehicle and laid flat to allow ReSeal to reach the leak. The rim and/or tire bead must be clean and not damaged. In some cases the tire may have to be removed from the wheel rim to clean the bead set.